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Molecular Profile | FGFR2 K660N FGFR2 amp |
Therapy | Fexagratinib |
Indication/Tumor Type | stomach cancer |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR2 K660N FGFR2 amp | stomach cancer | predicted - resistant | Fexagratinib | Preclinical - Cell culture | Actionable | In a preclinical study, a gastric cancer cell line harboring an FGFR2 amplification was found to have developed resistance to AZD4547 after prolonged exposure in culture, and was subsequently found to have acquired FGFR2 K660N (PMID: 32973082). | 32973082 |
PubMed Id | Reference Title | Details |
---|---|---|
(32973082) | Futibatinib Is a Novel Irreversible FGFR 1-4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors. | Full reference... |