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Molecular Profile | JAK2 V617F |
Therapy | A-1155463 |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK2 V617F | acute myeloid leukemia | sensitive | A-1155463 | Preclinical | Actionable | In a preclinical study, acute myeloid leukemia cells harboring JAK2 V617F demonstrated sensitivity to A-1155463 in culture (PMID: 25787766). | 25787766 |
PubMed Id | Reference Title | Details |
---|---|---|
(25787766) | Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy. | Full reference... |