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Molecular Profile PIK3CA E542K
Therapy MK2206
Indication/Tumor Type stomach cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA E542K stomach cancer sensitive MK2206 Preclinical - Cell culture Actionable In a preclinical study, MK2206 treatment induced cell death and inhibited proliferation of a gastric cancer cell line harboring PIK3CA E542K in culture (PMID: 32439931). 32439931
PubMed Id Reference Title Details
(32439931) A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity. Full reference...