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| Molecular Profile | HRAS G12V |
| Therapy | RAF265 + Trametinib |
| Indication/Tumor Type | urinary bladder cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| HRAS G12V | urinary bladder cancer | sensitive | RAF265 + Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, RAF265 and Mekinist (trametinib) combination treatment inhibited colony formation compared to RAF265 alone in cultured cells harboring HRAS G12V (PMID: 34554931). | 34554931 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34554931) | RAF1 amplification drives a subset of bladder tumors and confers sensitivity to MAPK-directed therapeutics. | Full reference... |