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Molecular Profile | MAP2K1 I111R |
Therapy | CI-1040 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
MAP2K1 I111R | Advanced Solid Tumor | predicted - resistant | CI-1040 | Preclinical - Biochemical | Actionable | In a preclinical study, CI-1040 (PD184352) did not inhibit kinase activity of MAP2K1 I111R in an in vitro assay (PMID: 12370306). | 12370306 |
PubMed Id | Reference Title | Details |
---|---|---|
(12370306) | Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352. | Full reference... |