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| Molecular Profile | BRAF V600E TET2 V1199E |
| Therapy | Vemurafenib |
| Indication/Tumor Type | high grade glioma |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E TET2 V1199E | high grade glioma | resistant | Vemurafenib | Preclinical - Cell culture | Actionable | In a preclinical study, a glioma cell line harboring BRAF V600E developed resistance after prolonged exposure to Zelboraf (vemurafenib) in culture, and was subsequently found to have acquired TET2 V1199E (PMID: 34433654). | 34433654 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34433654) | Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAFV600E-Mutant Human Glioma. | Full reference... |