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Molecular Profile | BRAF N486_P490del |
Therapy | Vemurafenib |
Indication/Tumor Type | melanoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF N486_P490del | melanoma | resistant | Vemurafenib | Preclinical - Cell culture | Actionable | In a preclinical study, Zelboraf (vemurafenib) failed to reduce phosphorylation of Mek and Erk and did not inhibit viability of a melanoma cell line harboring BRAF N486_P490del in culture (PMID: 26996308). | 26996308 |
PubMed Id | Reference Title | Details |
---|---|---|
(26996308) | Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. | Full reference... |