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| Molecular Profile | BRAF N486_P490del BRAF R509H |
| Therapy | GDC0879 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF N486_P490del BRAF R509H | Advanced Solid Tumor | sensitive | GDC0879 | Preclinical - Biochemical | Actionable | In a preclinical study, GDC0879 reduced Mek phosphorylation in transformed cells expressing BRAF N486_P490del and R509H in culture (PMID: 26996308). | 26996308 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26996308) | Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. | Full reference... |