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| Molecular Profile | FGFR2 H544Q |
| Therapy | Dovitinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR2 H544Q | Advanced Solid Tumor | predicted - resistant | Dovitinib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing FGFR2 H544Q were resistant to treatment with Dovitinib (TKI258) in culture (PMID: 34272467). | 34272467 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34272467) | Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer. | Full reference... |