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Molecular Profile PIK3CA N345K
Therapy Alpelisib
Indication/Tumor Type head and neck squamous cell carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA N345K head and neck squamous cell carcinoma predicted - sensitive Alpelisib Preclinical - Cell culture Actionable In a preclinical study, treatment with Piqray (alpelisib) resulted in inhibition of proliferation and increased apoptosis in a head and neck squamous cell carcinoma cell line expressing PIK3CA N345K in culture (PMID: 34779417). 34779417
PubMed Id Reference Title Details
(34779417) Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma. Full reference...