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| Molecular Profile | MDM2 amp |
| Therapy | BI 907828 |
| Indication/Tumor Type | liposarcoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MDM2 amp | liposarcoma | predicted - sensitive | BI 907828 | Case Reports/Case Series | Actionable | In a Phase I trial, BI 907828 treatment led to a partial response in 3 of 7 patients with liposarcoma, all responders harbored MDM2 amplification (Ann Oncol 32 (2021): S1294; NCT03449381). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| 1548P A phase Ia/Ib, dose-escalation/expansion study of the MDM2–p53 antagonist BI 907828 in patients (pts) with advanced/metastatic sarcoma | Full reference... |