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| Molecular Profile | CD274 over exp POLE R34L |
| Therapy | Pembrolizumab |
| Indication/Tumor Type | small intestine adenocarcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CD274 over exp POLE R34L | small intestine adenocarcinoma | predicted - sensitive | Pembrolizumab | Case Reports/Case Series | Actionable | In a clinical case study, Keytruda (pembrolizumab) treatment resulted in a reduction of primary tumor and metastatic lesions and an ongoing progression-free survival at 31 months in a patient with microsatellite stable (MSS) ileum adenocarcinoma that had high CD274 (PD-L1) expression (TPS = 75%) and harbored POLE R34L, but had low tumor mutational burden (PMID: 34875656). | 34875656 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34875656) | PD-1 Blockade Elicits Ongoing Remission in Two Cases of Refractory Microsatellite-Stable Cancer Harboring a POLE Mutation. | Full reference... |