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| Molecular Profile | KEAP1 inact mut |
| Therapy | Fluorouracil |
| Indication/Tumor Type | gallbladder cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KEAP1 inact mut | gallbladder cancer | resistant | Fluorouracil | Preclinical | Actionable | In a preclinical study, gallbladder cancer cells harboring KEAP inactivating mutations had increased NRF2 activation and demonstrated resistance to Adrucil (fluorouracil) in culture (PMID: 18692501). | 18692501 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (18692501) | Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. | Full reference... |