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Molecular Profile CDKN2A loss NRAS mut
Therapy Abemaciclib
Indication/Tumor Type melanoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CDKN2A loss NRAS mut melanoma predicted - sensitive Abemaciclib Case Reports/Case Series Actionable In a Phase I trial, Verzenio (abemaciclib) resulted in a partial response in a melanoma patient with CDKN2A loss and NRAS mutation (PMID: 27217383). 27217383
PubMed Id Reference Title Details
(27217383) Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors. Full reference...