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| Molecular Profile | CDKN2A loss |
| Therapy | Alvocidib |
| Indication/Tumor Type | melanoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CDKN2A loss | melanoma | sensitive | Alvocidib | Preclinical | Actionable | In a preclinical study, melanoma cell lines with CDKN2A loss demonstrated a greater sensitivity to Alvocidib (flavopiridol) as compared to melanoma cell lines positive for CDKN2A (PMID: 12777976). | 12777976 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (12777976) | The effect of flavopiridol on the growth of p16+ and p16- melanoma cell lines. | Full reference... |