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Molecular Profile | BRAF class 1 |
Therapy | Exarafenib |
Indication/Tumor Type | melanoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF class 1 | melanoma | predicted - sensitive | Exarafenib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Exarafenib (KIN-2787) treatment led to inhibition of tumor growth in a melanoma cell line xenograft model harboring a BRAF class 1 mutation (J of Clin Oncol 39, no. 15_suppl (May 20, 2021) 3116-3116). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
The next-generation pan-RAF inhibitor, KIN-2787, is active in class II and class III BRAF mutant models. | Full reference... |