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Molecular Profile | CDKN2A loss |
Therapy | ZK 304709 |
Indication/Tumor Type | neuroendocrine tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CDKN2A loss | neuroendocrine tumor | sensitive | ZK 304709 | Preclinical | Actionable | In a preclinical study, an orthotopic mouse model treated with ZK 304709 demonstrated an 80% tumor growth reduction in neuroendocrine tumor cells with CDKN2A loss (PMID: 18829975). | 18829975 |
PubMed Id | Reference Title | Details |
---|---|---|
(18829975) | The oral multitarget tumour growth inhibitor, ZK 304709, inhibits growth of pancreatic neuroendocrine tumours in an orthotopic mouse model. | Full reference... |