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Molecular Profile | VHL loss |
Therapy | Bevacizumab |
Indication/Tumor Type | renal cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
VHL loss | renal cell carcinoma | sensitive | Bevacizumab | Preclinical | Actionable | In a preclinical study, clear cell renal cell carcinoma xenograft models with VHL loss demonstrated sensitivity to Avastin (bevacizumab) (PMID: 22931246). | 22931246 |
PubMed Id | Reference Title | Details |
---|---|---|
(22931246) | Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy. | Full reference... |