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| Molecular Profile | VHL loss |
| Therapy | ELR510444 |
| Indication/Tumor Type | renal cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| VHL loss | renal cell carcinoma | sensitive | ELR510444 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, renal cell carcinoma cells deficient for VHL were sensitive to ELR510444 both in culture and in cell line xenograft models (PMID: 22295124). | 22295124 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (22295124) | ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma. | Full reference... |