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Molecular Profile JAK2 V617F
Therapy IMG-7289 + Ruxolitinib
Indication/Tumor Type myeloproliferative neoplasm
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK2 V617F myeloproliferative neoplasm predicted - sensitive IMG-7289 + Ruxolitinib Preclinical Actionable In a preclinical study, combination treatment with Jakafi (ruxolitinib) and IMG-7289 demonstrated a synergistic effect, and led to decreased leukocyte and platelet counts, decreased spleen size, and decreased bone marrow stem and progenitor cell expansion in a transgenic mouse model expressing JAK2 V617F (PMID: 31723778). 31723778
PubMed Id Reference Title Details
(31723778) LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone. Full reference...