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| Molecular Profile | FGFR1 V561M |
| Therapy | Futibatinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR1 V561M | Advanced Solid Tumor | resistant | Futibatinib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing FGFR1 V561M were resistant to Lytgobi (futibatinib) in culture (PMID: 40526877). | 40526877 |
| FGFR1 V561M | Advanced Solid Tumor | resistant | Futibatinib | Preclinical - Cell culture | Actionable | In a preclinical study, treatment with Lytgobi (futibatinib) failed to inhibit cell growth and Fgfr1 downstream signaling in cells expressing FGFR1 V561M in culture (PMID: 34114373). | 34114373 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34114373) | GZD824 overcomes FGFR1-V561F/M mutant resistance in vitro and in vivo. | Full reference... |
| (40526877) | Functional Characterization of Variants of Unknown Significance of Fibroblast Growth Factor Receptors 1-4 and Comparison With AI Model-Based Prediction. | Full reference... |