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| Molecular Profile | CSF3R N579Y |
| Therapy | Ruxolitinib |
| Indication/Tumor Type | hematologic cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CSF3R N579Y | hematologic cancer | sensitive | Ruxolitinib | Preclinical - Cell culture | Actionable | In a preclinical study, Jakafi (ruxolitinib) treatment inhibited colony formation and decreased viability of transformed cells expressing CSF3R N579Y in culture (PMID: 36579444). | 36579444 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36579444) | A novel colony stimulating factor 3 receptor activating mutation identified in a patient with chronic neutrophilic leukemia. | Full reference... |