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Molecular Profile | FLT3 D835H |
Therapy | Crenolanib |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 D835H | acute myeloid leukemia | sensitive | Crenolanib | Preclinical | Actionable | In a preclinical study, Crenolanib (CP-868596) inhibited Flt3 phosphorylation and induced apoptosis in leukemia cells expressing FLT3 D835H (PMID: 24623852). | 24623852 |
PubMed Id | Reference Title | Details |
---|---|---|
(24623852) | Crenolanib is a selective type I pan-FLT3 inhibitor. | Full reference... |