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Molecular Profile CSF3R N579Y CSF3R Q739* CSF3R Q741*
Therapy Ruxolitinib
Indication/Tumor Type chronic neutrophilic leukemia
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CSF3R N579Y CSF3R Q739* CSF3R Q741* chronic neutrophilic leukemia predicted - sensitive Ruxolitinib Preclinical - Patient cell culture Actionable In a preclinical study, Jakafi (ruxolitinib) treatment inhibited colony formation of hematopoietic progenitor cells isolated from the bone marrow of a patient with chronic neutrophilic leukemia harboring CSF3R N579Y, Q739*, and Q741* in culture (PMID: 36579444). 36579444
PubMed Id Reference Title Details
(36579444) A novel colony stimulating factor 3 receptor activating mutation identified in a patient with chronic neutrophilic leukemia. Full reference...