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Molecular Profile | CSF3R N579Y CSF3R Q739* CSF3R Q741* |
Therapy | Ruxolitinib |
Indication/Tumor Type | chronic neutrophilic leukemia |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CSF3R N579Y CSF3R Q739* CSF3R Q741* | chronic neutrophilic leukemia | predicted - sensitive | Ruxolitinib | Preclinical - Patient cell culture | Actionable | In a preclinical study, Jakafi (ruxolitinib) treatment inhibited colony formation of hematopoietic progenitor cells isolated from the bone marrow of a patient with chronic neutrophilic leukemia harboring CSF3R N579Y, Q739*, and Q741* in culture (PMID: 36579444). | 36579444 |
PubMed Id | Reference Title | Details |
---|---|---|
(36579444) | A novel colony stimulating factor 3 receptor activating mutation identified in a patient with chronic neutrophilic leukemia. | Full reference... |