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Molecular Profile BTK T474I
Therapy Pirtobrutinib
Indication/Tumor Type chronic lymphocytic leukemia
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BTK T474I chronic lymphocytic leukemia predicted - resistant Pirtobrutinib Case Reports/Case Series Actionable In a clinical case study, a patient with chronic lymphocytic leukemia harboring BTK C481S experienced progressive disease after an initial response on treatment with Jaypirca (pirtobrutinib) and was found to have acquired BTK T474I and lost BTK C481S (PMID: 39048721). 39048721
BTK T474I chronic lymphocytic leukemia predicted - resistant Pirtobrutinib Case Reports/Case Series Actionable In a clinical case study, two patients with chronic lymphocytic leukemia who previously responded to Jaypirca (pirtobrutinib) treatment were found to have acquired BTK T474I upon disease progression (PMID: 35196427). 35196427
PubMed Id Reference Title Details
(35196427) Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors. Full reference...
(39048721) Mutation in Bruton Tyrosine Kinase (BTK) A428D confers resistance To BTK-degrader therapy in chronic lymphocytic leukemia. Full reference...