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| Molecular Profile | PALB2 inact mut |
| Therapy | Cisplatin + Gemcitabine |
| Indication/Tumor Type | pancreatic ductal adenocarcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PALB2 inact mut | pancreatic ductal adenocarcinoma | sensitive | Cisplatin + Gemcitabine | Phase II | Actionable | In a Phase II trial, patients with pancreatic ductal adenocarcinoma harboring either a germline BRCA1, BRCA2, or PALB2 inactivating mutation demonstrated a response rate of 65.2% (15/23), a median progression-free survival of 9.7 months, a median overall survival of 16.4 months, and a disease control rate of 78.3% (18/23) when treated with a combination of Gemzar (gemcitabine) and Platinol (cisplatin) (PMID: 31976786). | 31976786 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31976786) | Randomized, Multicenter, Phase II Trial of Gemcitabine and Cisplatin With or Without Veliparib in Patients With Pancreas Adenocarcinoma and a Germline BRCA/PALB2 Mutation. | Full reference... |