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| Molecular Profile | BTK T474I |
| Therapy | Fenebrutinib |
| Indication/Tumor Type | diffuse large B-cell lymphoma |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK T474I | diffuse large B-cell lymphoma | resistant | Fenebrutinib | Preclinical - Cell culture | Actionable | In a preclinical study, a diffuse large B-cell lymphoma cell line expressing BTK T474I demonstrated resistance to Fenebrutinib (GDC-0853) in culture (PMID: 35196427). | 35196427 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (35196427) | Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors. | Full reference... |