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| Molecular Profile | IDH2 R140Q |
| Therapy | SH1573 |
| Indication/Tumor Type | hematologic cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| IDH2 R140Q | hematologic cancer | predicted - sensitive | SH1573 | Preclinical - Cell culture | Actionable | In a preclinical study, SH1573 treatment decreased 2-HG levels and increased differentiation of a tumor cell line expressing IDH2 R140Q in culture (PMID: 34221866). | 34221866 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34221866) | Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China. | Full reference... |