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Molecular Profile CD274 positive
Therapy Balstilimab + Zalifrelimab
Indication/Tumor Type cervical cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 positive cervical cancer predicted - sensitive Balstilimab + Zalifrelimab Phase II Actionable In a Phase II study, a combination of Balstilimab (AGEN2034) and Zalifrelimab (AGEN1884) resulted in an objective response rate of 32.8% (22/67) in patients with recurrent and/or metastatic cervical cancer positive for CD274 (PD-L1) (PMID: 34932394; NCT03495882). 34932394
PubMed Id Reference Title Details
(34932394) Dual PD-1 and CTLA-4 Checkpoint Blockade Using Balstilimab and Zalifrelimab Combination as Second-Line Treatment for Advanced Cervical Cancer: An Open-Label Phase II Study. Full reference...