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Molecular Profile | PIK3CA mutant |
Therapy | BAY1082439 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA mutant | Advanced Solid Tumor | sensitive | BAY1082439 | Preclinical | Actionable | In a preclinical study, BAY1082439 induced regression in xenograft models of advanced solid tumors with PIK3CA mutations (Cancer Res April 15, 2012 72; 2799). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Abstract 2799: BAY 1082439, a highly selective and balanced PI3Kalpha/beta inhibitor demonstrated potent activity in tumors with activated PI3Kalpha and loss-of-function of PTEN | Full reference... |