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Molecular Profile | FGFR1 W4C FGFR1 amp |
Therapy | Rogaratinib |
Indication/Tumor Type | estrogen-receptor positive breast cancer |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR1 W4C FGFR1 amp | estrogen-receptor positive breast cancer | no benefit | Rogaratinib | Preclinical - Pdx | Actionable | In a preclinical study, Rogaratinib (BAY 1163877) treatment did not inhibit tumor growth in an ER-positive breast cancer patient-derived xenograft (PDX) model with FGFR1 W4C and FGFR1 amplification (PMID: 34593528). | 34593528 |
PubMed Id | Reference Title | Details |
---|---|---|
(34593528) | High FGFR1-4 mRNA Expression Levels Correlate with Response to Selective FGFR Inhibitors in Breast Cancer. | Full reference... |