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Molecular Profile FGFR2 M538I
Therapy FIIN-3 + Fulvestrant
Indication/Tumor Type breast cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 M538I breast cancer sensitive FIIN-3 + Fulvestrant Preclinical - Cell culture Actionable In a preclinical study, Faslodex (fulvestrant) and FIIN-3 combination treatment decreased viability of ESR1-positive breast cancer cells expressing FGFR2 M538I in culture (PMID: 32723837). 32723837
PubMed Id Reference Title Details
(32723837) Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER+ Metastatic Breast Cancer. Full reference...