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| Molecular Profile | FGFR3 K650E |
| Therapy | Infigratinib |
| Indication/Tumor Type | high grade glioma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR3 K650E | high grade glioma | predicted - sensitive | Infigratinib | Case Reports/Case Series | Actionable | In a Phase II trial, Truseltiq (infigratinib) treatment resulted in limited efficacy with a 6-month progression-free survival (PFS) rate of 16.0%, a median PFS of 1.7 months, an objective response rate of 4.8% (1/21), and median overall survival of 6.7 months in patients with recurrent gliomas harboring alterations in FGFR1 or FGFR3, however, resulted in stable disease with PFS of 12.9 months in a patient harboring FGFR3 K650E (PMID: 35344029; NCT01975701). | 35344029 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (35344029) | Infigratinib in Patients with Recurrent Gliomas and FGFR Alterations: A Multicenter Phase II Study. | Full reference... |