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| Molecular Profile | JAK2 V617F JAK2 G935R |
| Therapy | NVP-BVB808 |
| Indication/Tumor Type | hematologic cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| JAK2 V617F JAK2 G935R | hematologic cancer | resistant | NVP-BVB808 | Preclinical | Actionable | In a preclinical study, immune cells expressing the JAK2 V617F and JAK2 G935R double mutation demonstrated resistance to NVP-BVB808 in culture (PMID: 22271575). | 22271575 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (22271575) | Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. | Full reference... |