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| Molecular Profile | CD274 over exp STK11 A205Rfs*82 |
| Therapy | Pembrolizumab |
| Indication/Tumor Type | lung squamous cell carcinoma |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CD274 over exp STK11 A205Rfs*82 | lung squamous cell carcinoma | predicted - resistant | Pembrolizumab | Case Reports/Case Series | Actionable | In a clinical case study, a lung squamous cell carcinoma patient with high CD274 (PD-L1) expression progressed after initial response to Keytruda (pembrolizumab) and through subsequent ctDNA testing was found to have acquired STK11 A205Rfs*82 (PMID: 33832284). | 33832284 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (33832284) | The influence of STK11 mutation on acquired resistance to immunotherapy in advanced non-small cell lung cancer with Lynch syndrome: a case report and literature review. | Full reference... |