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Molecular Profile | FLT3 exon 14 ins FLT3 N701K |
Therapy | Quizartinib |
Indication/Tumor Type | hematologic cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins FLT3 N701K | hematologic cancer | sensitive | Quizartinib | Preclinical - Cell culture | Actionable | In a preclinical study, Vanflyta (quizartinib) treatment inhibited growth of transformed hematologic cells expressing FLT3-ITD and FLT3 N701K in culture (PMID: 33780043). | 33780043 |
PubMed Id | Reference Title | Details |
---|---|---|
(33780043) | A noncanonical FLT3 gatekeeper mutation disrupts gilteritinib binding and confers resistance. | Full reference... |