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Molecular Profile MSH2 loss
Therapy N/A
Indication/Tumor Type endometrial carcinoma
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MSH2 loss endometrial carcinoma not applicable N/A Preclinical Emerging Preclinical shRNA mediated-inhibition of POLB in human endometrial carcinoma cells with MSH2 loss resulted in synthetic lethality, suggesting POLB may be a promising therapeutic target for MSH2 deficient cancer cells (PMID: 20227038). 20227038
PubMed Id Reference Title Details
(20227038) DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1. Full reference...