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Molecular Profile | MSH2 loss |
Therapy | N/A |
Indication/Tumor Type | endometrial carcinoma |
Response Type | not applicable |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
MSH2 loss | endometrial carcinoma | not applicable | N/A | Preclinical | Emerging | Preclinical shRNA mediated-inhibition of POLB in human endometrial carcinoma cells with MSH2 loss resulted in synthetic lethality, suggesting POLB may be a promising therapeutic target for MSH2 deficient cancer cells (PMID: 20227038). | 20227038 |
PubMed Id | Reference Title | Details |
---|---|---|
(20227038) | DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1. | Full reference... |