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Molecular Profile | KMT2A rearrange |
Therapy | Revumenib |
Indication/Tumor Type | acute leukemia |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KMT2A rearrange | acute leukemia | predicted - sensitive | Revumenib | FDA approved | Actionable | In a Phase I trial (AUGMENT 101), Revuforj (revumenib) treatment demonstrated acceptable safety and resulted in a complete remission or complete remission with partial hematologic recovery (CR/CRh) rate of 30% (18/60) and median duration of response of 9.1 mo in adult and pediatric patients 1 year or older with acute leukemia harboring KMT2A rearrangements or NPM1 mutations, with a CR/CRh rate of 33% (15/46) and median time to CR/CRh of 2.0 mo in KMT2A rearranged patients (PMID: 36922593; NCT04065399). | 36922593 detail... |
PubMed Id | Reference Title | Details |
---|---|---|
(36922593) | The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia. | Full reference... |
Revuforj (revumenib) FDA Drug Label | Full reference... |