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Molecular Profile KMT2A rearrange
Therapy Revumenib
Indication/Tumor Type acute leukemia
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KMT2A rearrange acute leukemia predicted - sensitive Revumenib FDA approved Actionable In a Phase I trial (AUGMENT 101), Revuforj (revumenib) treatment demonstrated acceptable safety and resulted in a complete remission or complete remission with partial hematologic recovery (CR/CRh) rate of 30% (18/60) and median duration of response of 9.1 mo in adult and pediatric patients 1 year or older with acute leukemia harboring KMT2A rearrangements or NPM1 mutations, with a CR/CRh rate of 33% (15/46) and median time to CR/CRh of 2.0 mo in KMT2A rearranged patients (PMID: 36922593; NCT04065399). 36922593 detail...
PubMed Id Reference Title Details
(36922593) The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia. Full reference...
Revuforj (revumenib) FDA Drug Label Full reference...