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| Molecular Profile | BRAF K601E |
| Therapy | Vemurafenib |
| Indication/Tumor Type | melanoma |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF K601E | melanoma | no benefit | Vemurafenib | Case Reports/Case Series | Actionable | In a clinical case study, Zelboraf (vemurafenib) treatment resulted in transient disease stabilization followed by metastatic progression in a patient with metastatic melanoma harboring BRAF K601E (PMID: 31182949). | 31182949 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31182949) | Lack of Response to Vemurafenib in Melanoma Carrying BRAF K601E Mutation. | Full reference... |