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| Molecular Profile | RET V804L |
| Therapy | APS03118 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET V804L | Advanced Solid Tumor | predicted - sensitive | APS03118 | Preclinical - Biochemical | Actionable | In a preclinical study, APS03118 inhibited the enzymatic activity of RET V804L in an in vitro assay (J Clin Oncol 40, no. 16_suppl (June 1, 2022)). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| The development of APS03118, a potent next-generation RET inhibitor for treating RET-inhibitor-resistant patients. | Full reference... |