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Molecular Profile | RET C634W |
Therapy | APS03118 |
Indication/Tumor Type | thyroid cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET C634W | thyroid cancer | predicted - sensitive | APS03118 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, APS03118 treatment inhibited proliferation of a thyroid cancer cell line harboring RET C634W in culture and inhibited tumor growth in a xenograft model (J Clin Oncol 40, no. 16_suppl (June 1, 2022)). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
The development of APS03118, a potent next-generation RET inhibitor for treating RET-inhibitor-resistant patients. | Full reference... |