Profile Response Detail

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Molecular Profile ATM negative
Therapy Ceralasertib + Durvalumab
Indication/Tumor Type stomach cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM negative stomach cancer predicted - sensitive Ceralasertib + Durvalumab Phase II Actionable In a Phase II trial, Ceralasertib (AZD6738) and Imfinzi (durvalumab) combination therapy resulted in an overall response rate of 22.6% (7/31, all partial responses), disease control rate of 58.1%, and median progression-free survival (mPFS) of 3.0 mo in advanced gastric cancer patients, with improved mPFS (5.60 vs 1.65 mo; HR 0.13, p<0.001) in patients with ATM protein loss and/or homologous repair deficiency (HRD) compared to those with intact ATM expression or HR proficiency (PMID: 35790315; NCT03780608). 35790315
PubMed Id Reference Title Details
(35790315) Phase II study of ceralasertib (AZD6738) in combination with durvalumab in patients with advanced gastric cancer. Full reference...