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| Molecular Profile | PTEN del |
| Therapy | VS-5584 |
| Indication/Tumor Type | prostate cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN del | prostate cancer | sensitive | VS-5584 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, VS-5584 inhibited PI3K/mTOR signaling and cell proliferation in a human prostate cancer cell line harboring a PTEN deletion in culture, and inhibited PI3K/MTOR signaling and tumor growth in xenograft models (PMID: 23270925). | 23270925 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23270925) | VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. | Full reference... |