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Molecular Profile | FLT3 exon 14 ins IDH1 R132H |
Therapy | AGI-5198 + Crenolanib |
Indication/Tumor Type | hematologic cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins IDH1 R132H | hematologic cancer | sensitive | AGI-5198 + Crenolanib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing FLT3-ITD and IDH1 R132H demonstrated increased sensitivity to treatment with the combination of Crenolanib (CP-868596) and AGI-5198 compared to treatment with Crenolanib (CP-868596) alone in culture (PMID: 30651561). | 30651561 |
PubMed Id | Reference Title | Details |
---|---|---|
(30651561) | Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms. | Full reference... |