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Molecular Profile | FLT3 exon 14 ins NRAS Q61K |
Therapy | FF-10101 + Trametinib |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins NRAS Q61K | acute myeloid leukemia | predicted - sensitive | FF-10101 + Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, treatment with the combination of FF-10101 and Mekinist (trametinib) resulted in decreased viability of acute myeloid leukemia cells harboring a FLT3-ITD mutation and expressing NRAS Q61K compared to treatment with FF-10101 alone in culture (PMID: 35395091). | 35395091 |
PubMed Id | Reference Title | Details |
---|---|---|
(35395091) | The Irreversible FLT3 Inhibitor FF-10101 Is Active Against a Diversity of FLT3 Inhibitor Resistance Mechanisms. | Full reference... |