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Molecular Profile | NRAS Q61K |
Therapy | Everolimus + RO5126766 |
Indication/Tumor Type | thyroid cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS Q61K | thyroid cancer | predicted - sensitive | Everolimus + RO5126766 | Case Reports/Case Series | Actionable | In a Phase I trial, the combination of Afinitor (everolimus) and RO5126766 (VS-6766) resulted in a partial response in a patient with thyroid cancer harboring NRAS Q61K (Journal of Clinical Oncology 2022 40:16_suppl, 9018-9018; NCT02407509). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Phase I trial of the RAF/MEK clamp VS-6766 in combination with everolimus using an intermittent schedule with expansion in NSCLC across multiple KRAS variants. | Full reference... |