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Molecular Profile | BRAF mutant |
Therapy | PLX8394 |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF mutant | melanoma | sensitive | PLX8394 | Preclinical | Actionable | In a preclinical study, PLX8394 blocked survival and growth of vemurafenib/PLX4720-resistant melanoma cells harboring BRAF V600E splice variants in culture (PMID: 24422853). | 24422853 |
PubMed Id | Reference Title | Details |
---|---|---|
(24422853) | Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors. | Full reference... |