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| Molecular Profile | APC inact mut |
| Therapy | BMS-906024 |
| Indication/Tumor Type | desmoid tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC inact mut | desmoid tumor | predicted - sensitive | BMS-906024 | Case Reports/Case Series | Actionable | In a clinical case study, BMS-906024 treatment resulted in a partial response that lasted for at least 2.6 years in a patient with a desmoid tumor harboring an inactivating APC mutation (PMID: 34590610). | 34590610 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34590610) | Activity of the Gamma Secretase Inhibitor AL101 in Desmoid Tumors: A Case Report of 2 Adult Cases. | Full reference... |