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Molecular Profile | APC T1556Nfs*3 |
Therapy | Celecoxib + Nirogacestat |
Indication/Tumor Type | desmoid tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
APC T1556Nfs*3 | desmoid tumor | predicted - sensitive | Celecoxib + Nirogacestat | Case Reports/Case Series | Actionable | In a clinical case study, addition of Ogsiveo (nirogacestat) to Celecoxib treatment resulted in a reduction in tumor size and stable disease that was ongoing for at least 17 months in a pediatric patient with a desmoid tumor harboring APC T1556Nfs*3 (PMID: 32762028). | 32762028 |
PubMed Id | Reference Title | Details |
---|---|---|
(32762028) | Safety and efficacy of gamma-secretase inhibitor nirogacestat (PF-03084014) in desmoid tumor: Report of four pediatric/young adult cases. | Full reference... |