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| Molecular Profile | KIT V560G |
| Therapy | Nilotinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT V560G | Advanced Solid Tumor | sensitive | Nilotinib | Preclinical | Actionable | In a preclinical study, transformed cells expressing KIT V560G demonstrated inhibition of cell proliferation and tumor regression both in culture and in vivo when treated with Tasigna (nilotinib) (PMID: 20442311). | 20442311 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (20442311) | Preclinical evaluation of nilotinib efficacy in an imatinib-resistant KIT-driven tumor model. | Full reference... |